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Indlæg: 19 nov 2017 21:56 
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David Nichols, grundlægger af Heffter Instituttet og en af den psykedeliske forsknings grand old men har for nyligt advaret mod daglig brug af LSD selv i små doser, da der er risiko for at man kan udvikle alvorlige hjerteproblemer:

Citat:
A more serious issue concerns other receptors that LSD activates. In particular, LSD is a potent activator of the serotonin 5-HT2B receptor. Activation of that receptor stimulates growth of cardiac ventricular and valve tissue. The drug combination marketed as Fen-Phen led to stimulation of the 5-HT2B receptor and caused severe cardiac valvulopathy (valvular heart disease; HVD) in patients. It was withdrawn from the market and led to costly lawsuits for the drug company. Similarly, a drug marketed as Permax for treating Parkinson’s disease also stimulated the 5-HT2B receptor, leading to HVD in a certain percentage of patients, and it too was withdrawn from the market. This condition is very serious, as the only long-term treatment for HVD is cardiac valve replacement surgery.

Some may trivialize this concern, in the belief that microdoses are too low to cause HVD. A 2017 study, however, has reported that the kinetics of LSD binding to the 5-HT2B receptor show that it is “trapped” within the receptor for many hours, and this retention may allow it to accumulate in the receptor. Thus, even low doses could be problematic. Although some of this discussion may be speculative, the microdose user must ask themselves whether the risk is worth it. And, again, we lack rigorous studies that could help us better assess this aspect of LSD's method of action.


http://heffter.org/microdosing-lsd-research-potential/

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Senest rettet af Skinny Sweaty Man 19 nov 2017 22:11, rettet i alt 1 gang.

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Indlæg: 19 nov 2017 22:01 
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Vigtigt indspark til et emne, som synes at være meget unuanceret, i retningen af, at der kun er positive effekter ved mikrodosering.

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Indlæg: 20 nov 2017 11:46 
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Virkelig interessant!


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Indlæg: 20 nov 2017 17:53 
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Godt med noget perspektiv på tingene. Og det er ting som de her, folk der mikrodoserer bør overveje. Som Frugthat oplever jeg også en stemning omkring, at microdosing af psykedeliske stoffer er uden bivirkninger.

Men at tage et stof uden de store bivirkninger engang i mellem, i modsætning til hver dag, er to forskellige situationer.

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