Psychedelia.dk

GHB? Jeg giver dig ret i, at det kan være visuelt, men decideret psykedelisk? Jeg vil tro, at GHB vil virke beroligende og hyggeagtigt i et trip.

Bulletin 68
Title: High Times: an F in chemistry
When: 3/5/92 at 9:24 pm
Left by mark thompson (Level 30)

I was handed the High Times article about the Edgewood Arsenal mind-control
experiments and the case of Sergeant Stanley today. (High Times. March 1992
page 34).

While interesting, the first few paragraphs contained some rather dangerous
misinformation about the nature of nerve gasses and BZ:

"By the mid'60s, seven agents were being mass-produced and stockpiled.
There were two instantaneously lethal, anticholinergic {sic} nerve gasses
(Sarin and Soman, originally manufactured by Nazi chemists), a blister
agent, three "riot control" gases - CS, CN and DM, all of which were
heavily used in Vietnam - and an 80-hour dyphoric, incapacitating agent
called BZ (or quinuclidinyl benzylate), on of eight tested derivatives
of LSD. ..."

First of all, nerve gasses like the ones mentioned are organophosphate
antiCHOLINESTERASE agents, not antiCHOLINERGIC. In fact, the ANTIDOTE for
organophospate nerve gasses usually recommended is atropine, which is
anticholinergic. The enzyme cholinesterase breaks down acetylcholine.
When that enzyme is inhibited, too much acetylcholine builds up at nerve
junctions and the victim goes into convulsions and dies rather rapidly.
Anticholinergics inhibit the action of acetylcholine, and are useful as
antidotes. The insecticide Malathion is an organophosphate - and has been
sprayed on civilian populations in Los Angeles for the past several years, by
the way.

BZ, on the other hand IS an anticholinergic, with some of its effects being
similar to Datura or Jimson weed - delirium, dysphoria, hallucinations, amnesia
etc. BZ is also NOT EVEN vaguely related to LSD in it's chemical structure or
mode of action. It's very powerful, active in sub-milligram doses, if I recall.

Some of the confusion about BZ in the High Times article may have been due to a
mis-reading of the book "Acid Dreams" in which BZ is listed as a
mega-hallucinogen used by the CIA in it's MK/ULTRA program along with LSD.

I think I have the structures for some of the more notorious anticholinergic
hallucinogens around somewhere.


Bulletin 69
Title: Anticholinergics like BZ...
When: 3/5/92 at 9:29 pm
Left by mark thompson (Level 30)

Here's some info from "Medicinal Chemistry" edited by Alfred Burger:

Notice that JB-318, a hallucinogen mentioned in Richard Alpert's
"Be Here Now" is also listed...

------------------------------------------------------------------------
Table 60.6 Anticholinergic Hallucinogens



O {R1} O {R1}


\\ \ //| \\ \


O--C--C-OH O {R2} / / | O--C--C-OH


/ \ \\ \ / / | / \


/ {R2} /| O--C--C-OH \ | \ {R2}


\ / | / \ \ | \


\ \ \ {R2} \ | \


{R4} / \ \ | / /


| / | / | / /


N |N/ |N/


\ \


{R3} {R3}




(a)Open chain (b)Cyclic (c)Bicyclic


Ring Effective
Name R1 R2 R3 R4 System Dose Range
--------------- ------- ----------- --------------- ------- ------ ----------
Benactyzine Phenyl Phenyl CH2CH3 CH2CH3 a 50-200mg
JB-841 Phenyl Phenyl H b >100mg
JB-18 Phenyl Phenyl Allyl b >20mg
JB-868 Phenyl Phenyl (CH2)2NHN(CH3)2 b >20mg
JB-344 Phenyl Thionyl CH3 b >20mg
JB-318 Phenyl Phenyl CH2CH3 b 10-20mg
JB-851 Phenyl Phenyl (CH2)2N(CH3)2 b 10-20mg
JB-329 * Phenyl Cyclopentyl CH2CH3 b >10mg
JB-840 Phenyl Cyclohexyl CH3 b 10mg
Win-2299 Phenyl Cyclohexyl CH2CH3 CH
2CH3 a 10mg
JB-328 Phenyl Cyclohexyl CH2CH3 b 5-10mg
JB-336 Phenyl Phenyl CH3 b 5-10mg
QB, BZ Thionyl Phenyl c <1mg
--------------- ------- ----------- --------------- ------- ------ ----------
* Ditran is a mixture containing the pyrrolidylmethyl isomer
QB = "Quinuclidinyl benzylate" = BZ
JB-336 = "N-methyl-piperidylbenzylate"
JB-318 = "N-ethyl-3-piperidyl benzylate"
=============================================================================

Hmm. Ditran is listed too. That one's mentioned in "The Electric Kool-Aid Acid
Test" by Thomas Wolfe.