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I og med LSA ikke er aktivt i sig selv

LA-111, ergine, d-lysergamide. This is an active compound and has been established as a major component in morning glory seeds. It was assayed for human activity, by Albert Hofmann in self-trials back in 1947, well before this was known to be a natural compound. An i.m. administration of a 500 microgram dose led to a tired, dreamy state with an inability to maintain clear thoughts. After a short period of sleep, the effects were gone and normal baseline was recovered within five hours. Other observers have confirmed this clouding of consciousness leading to sleep. The epimer, inverted at C-8, is isoergine or d-isolysergamide, and is also a component of morning glory seeds. Hofmann tried a 2 milligram dose of this amide, and as with ergine, he experienced nothing but tiredness, apathy, and a feeling of emptiness. Both compounds are probably correctly dismissed as not being a contributor to the action of these seeds. It is important to note that ergine, as well as lysergic acid itself, is listed as a Schedule III drug in the Controlled Substances Act, as a depressant. This is, in all probability, a stratagem to control them as logical precursors to LSD.

LA-111, ergine, d-lysergamide. This is an active compound

After the discovery of the psychic effects of LSD, I had also tested lysergic acid amide [lysergamide] in a selfexperiment and established that it likewise evoked a dreamlike condition, but only with about a tenfold to twentyfold greater dose than LSD. This effect was characterized by a sensation of mental emptiness and the unreality and meaninglessness of the outer world, by enhanced sensitivity of hearing, and by a not unpleasant physical lassitude, which ultimately led to sleep.

Der findes mere potente, eksotiske og højst sandsynligt mere underholdende lovlige LSD-analoger.

For at citere fra TiHKAL

N-Morpholinyllysergamid
Methysergid

Og endelig ALD-52. 1-Acetyl-LSD