Hvorfor lave krystaller hvis man alligevel bare opløser dem i methanol igen når de er blevet dannet ? Det fede ville da netop være og have dem i krystaller...

da krystallerne ikke virker til at være så stabile (grundet den misfavning de har fået), ville det måske være en ide at lave et salt af den f.eks hydrochlorid eller sulfatsalt.. bare en tanke

Det ser komfortabelt ud


Krystallerne opløses kun i varm methanol!

Ja men han skriver da til sidst at at efter han har fået krystaller at han så opløser dem i methanol. sku da nedern og have svampe-træsprit

Jeg tror at du også vil få dannet en del 4-AcO-DMT hvis du bruger eddikesyre, da esterificeringen er syrekatalyseret. Tror jeg ville bruge HCl i stedet.

Hvis jeg skulle lave 4-AcO-DMT ville jeg bruge eddikesyre og en katalytisk mængde H2SO4, som normalt når man vil danne en ester.

Psilocybin bliver btw. nemt nedbrudt til psilocin, bla. ved opvarmning. Så det er temmelig sikkert psilocin du har hvis du har lavet fx. et varmt ethanol ekstrakt af svampe.

Dextrose > Der var en post i svampeforummet om samme emne hvor du også snakker om acetat, men krydsposter lige mine betænkeligheder her:



BTW så skriver Schulgin et sted at en blanding af ethanol og methanol skulle være det optimale opløsningsmiddel for psilocin.

This method permits rapid isolation of psilocin from hallucinogenic mushrooms by co-extraction of both psilocin and psilocybin. Dilute acetic acid is an excellent solvent for this purpose, because both compounds are very soluble in acetic acid and very little of other interfering substances are extracted, It is most likely some other compounds are co-extracted but are removed from psilocin in the ether extraction from the aqueous base. Psilocybin is completely dephosphorytated to psilocin by heating the acid extract. After addition of the base, extraction into ether should be performed promptly, because of decomposition of psilocin at a greater pH than 712. The extraction and dephosporylation steps produce reasonably pure psilocin from a small amount of mushroom material. Two grams of mushrooms will often be sufficient to obtain an infrared spectrum of psilocin (Fig. 1). Smaller mushrooms exhibits provide ample psilocin for mass spectral analysis (Fig. 2).

This method has been used in our laboratory for six months and has given excellent results in separating psilocin from methanol-soluble compounds. Other identification techniques such as gas chromatography and microcrystalline tests are possible on psilocin extracted by this method.

Experimental

A representative sample of 2 to 10g of dried mushrooms is ground to a fine powder by mortar and pestle. The powder is mixed with 100 mL of dilute acetic acid in a 250-mL beaker. The pH is readjusted to pH 4 with glacial acetic acid. After standing 1 h, the beaker is placed in a boiling water bath for 8 to 10 min or until the internal temperature of the acid mixture reaches 70°C. The beaker is removed and cooled to room temperature under running water. The acid mixture is separated from the mushroom powder by suction filtration using glass wool. The filtrate is brought to pH 8 with concentrated ammonium hydroxide and quickly extracted with two 50-mL portions of diethyl ether. Gentle mixing instead of shaking should be used to prevent an emulsion. The ether is dried over sodium sulfate, filtered, and evaporated under nitrogen with no applied heat.

Crude psilocin will appear as a greenish residue. Recrystallization from chloroform/heptane (1:3) yields white crystals. The resulting powder can then be submitted to infrared and mass spectral analyses.

After addition of the base, extraction into ether should be performed promptly, because of decomposition of psilocin at a greater pH than 712

der bruges en rundbundet kolbe, en soxhlet extractor, et svalerør og et bægerglas. en soxhlet er dog ikke noget man lige køber i matas, men den kan da sikkert findes på nettet.. dog er en soxhlet ikke en nødvendighed til ekstraktioner