SSRI hæmmer optagelsen af serotonin i synapse kløften og derfra har serotonin en længere effekt på receptorene. Det bliver ikke optaget af neuronet igen (eller bliver svagt optaget). Den eneste mulighed for at fjerne serotonin i synapse kløften er, når monoamine oxidase nedbryder transmitterstoffet. Når du tager et stof som hæmmer monoamine oxidase i synapse kløften vil der bliver en ophobning af serotonin og derved et overflow af signalinput, som resultere i serotoninsyndrom. Dette skaber følgenede symptomer:
http://en.wikipedia.org/wiki/Serotonin_syndrome#Signs_and_symptoms skrev:
Symptom onset is usually rapid, often occurring within minutes. Serotonin syndrome encompasses a wide range of clinical findings. Mild symptoms may only consist of increased heart rate, shivering, sweating, dilated pupils, myoclonus (intermittent tremor or twitching), as well as overresponsive reflexes.[1] Moderate intoxication includes additional abnormalities such as hyperactive bowel sounds, high blood pressure and hyperthermia; a temperature as high as 40 °C (104 °F) is common in moderate intoxication. The overactive reflexes and clonus in moderate cases may be greater in the lower limbs than in the upper limbs. Mental status changes include hypervigilance and agitation.[1] Severe symptoms include severe increases in heart rate and blood pressure that may lead to shock. Temperature may rise to above 41.1 °C (106.0 °F) in life-threatening cases. Other abnormalities include metabolic acidosis, rhabdomyolysis, seizures, renal failure, and disseminated intravascular coagulation; these effects usually arise as a consequence of hyperthermia.[1][3]
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