ville høre om en kemi-kyndig person kan be- eller afkræfte dette?
har fornyligt set et write-up på seperation af amfetamins isomer og det jo mildest talt en meget kompliceret process, så ville være interessant hvis nedestående er legitimt.
Og i så fald vil det ikke være et bedre opløsningsmiddel end ethanol til formålet?
Citat:
Resolution of racemic Amphetamine
Two mols, for example, 270 grams, of racemic amphetamine base are reacted with one mol (150 grams) of d-tartaric acid, thereby forming dl-amphetamine d-tartrate, a neutral salt. The neutral salt thus obtained is fully dissolved by the addition of sufficient, say about 1 liter, of absolute ethanol, and heating to about the boiling point. The solution is then allowed to cool to room temperature with occasional stirring to effect crystallization. The crystals are filtered off and will be found to contain a preponderance of the levo enantiomorph.
The residual solid in the mother liquors is repeatedly and systematically crystallized, yielding a further fraction of amphetamine d-tartrate which may be purified by recrystallization. d-amphetamine may be readily recovered from the mother liquors by the addition of tartaric acid thereto for the formation of acid tartrates and separation of d-amphetamine d-bitartrate by crystallization.
The free base of either optical isomer may be obtained by addition to the d-tartrate in the case of the levo isomer and the d-bitartrate in the case of the dextro isomer of alkali in excess, as, for example, by the addition of an aqueous solution of caustic soda, which will cause the base to separate as an oil which may be recovered and purified by any well-known procedure. The base is exactly neutralized with sulfuric acid to give the sulfate.
References
Merck Index 2918 PDR pp. 1450, 1711
OCDS Vol. 1 p.70 (1977)
I.N. p. 301
REM p.881
Nabenhauer, F.P.; U.S. Patent 2,276,508; March 17, 1942.