Selvfølgelig, Fritzie, måske skal jeg heller ikke skrive komplicerede, filosofiske tråde midt om natten efter at have kommet hjem godt overrislet fra byen.
NÅ, men nu har jeg læst dem, meget af det lyder skræmmende, det er jo selvfølgelig et spørgsmål om dosis, måske i endnu højere grad for det her stof end andre, lyder det som. Undrer mig stadig over at det virker antidepressivt, læste lidt videre og stødte på det her:
https://www.futurity.org/ketamine-depression-1860752/Hvor der står, at man har fundet ud af det måske virker på de opioide receptorer. Under alle omstændigheder lyder det som om de som sædvanligvis ikke er helt sikre på hvorfor det virker som det virker:
"The researchers say the findings from the new study may explain why ketamine works so quickly as an antidepressant: It activates the brain’s opioid receptors during its first phase of activity....
Revealing the role of the opioid system in the antidepressant effects of ketamine is critical in the effort to develop new antidepressants, the researchers say. For instance, glutamate receptor blockers may not have rapid antidepressant effects unless they also involve the opioid system, Williams says.
“THERE IS TRULY A LINK BETWEEN DEPRESSION, PAIN, AND OPIOID USE. YOU CAN’T GO AFTER ONE WITHOUT ADDRESSING THE OTHERS.”
“Psychiatry used opioids, barbiturates, and high doses of stimulants to treat depression 50 or 60 years ago,” Schatzberg says. “We have to properly examine the risks associated with using drugs of abuse—even in low doses—to treat depression. It’s not limited to ketamine; other antidepressant drugs that target the opioid system are in development now, too.”
While a standard opioid like morphine initially has an antidepressant effect, it promotes depression after repeated use, Williams says. People who are depressed take as much as 2.4 times as many opioids immediately after painful surgeries than those who aren’t depressed, he says. “There is truly a link between depression, pain, and opioid use,” Heifets says. “You can’t go after one without addressing the others.”
Det sidste er ikke helt min erfaring, hvis man holder pause i sit brug, har jeg ikke oplevet at opiater bevirker depression. Omvendt har jeg hørt det fra mange heltidsmisbrugere, at de bliver depressive/melankolske af det i længden