360 THE PROTECTIVE EFFECT OF SILYBUM MARIANUM AND
VITAMIN E ON LIVER TOXICITY INDUCED BY SODIUM
VALPROATE
H. Kalantari, F. Talibi. Depart. Of Pharmacology &Toxicology,
Pharmacy School, Ahvaz University Of Medical Sciences
Sodium valproate is an effective antiepileptic drug, which is widely
used in therapy. One of its side effects is liver toxicity. The aim
and purpose of this study was to find out the protective effects
of Silybum marianum and vitamin E in hepatotoxicity caused by
sodium valproate.
In this study the crude extract of Silybum marianum in doses of
100, 200 and 800 mg/kg and vitamin E in doses of 100, 200 and 400
mg/kg were orally administered to mice one hour before the toxic
dose of sodium valproate for one week. The positive control received
toxic dose of sodium valproate (500 mg/kg) and negative control
groups received normal saline and Seasame oil. On the 8th day, blood
was taken for measurement of enzyme activities such as SGOT &
SGPT and also liver tissues were taken for histopathological study.
Results showed that significant hepatoprotection was observed in
doses of 800 mg/kg of Silybum marianum and 400 mg/kg vitamin
E. Also it has been observed that the adjuvant dose of Silybum
marianum and vitamin E in doses of 100 mg/kg were synergistically
effective. In conclusion, this herbal extract and vitamin