Psychedelia.dk

Jeg stikker resten op i røven på søndag. Hvordan bærer jeg mig ad med det?

I'd say 30-60 mg orally would be a reasonable starting dose.

20-40% (oral), 36-71% (rectally), 100% (IV/IM), 10% (insufflated)
jeg ville fortrække numsen hvis du ikke vil skyde det.. but too late for that.

Er det virkelig kun 10% nasalt? Jeg syntes når jeg har spurgt rundt omkring, at det sagtens kunne svare sig at sniffe det.. But i guess not.. Har du evt en kilde, på bio tilgængeligheden?

"Morphine administered nasally to humans as a simple solution is only absorbed to a limited degree, with a bioavailability of the order of 10% compared with intravenous administration. This article describes the development of novel nasal morphine formulations based on chitosan, which, in the sheep model, provide a highly increased absorption with a 5- to 6-fold increase in bioavailability over simple morphine solutions. The chitosan-morphine nasal formulations have been tested in healthy volunteers in comparison with a slow i.v. infusion (over 30 min) of morphine. The results show that the nasal formulation was rapidly absorbed with a Tmax of 15 min or less and a bioavailability of nearly 60%. The shape of the plasma profile for nasal delivery of the chitosan-morphine formulation was similar to the one obtained for the slow i.v. administration of morphine. Furthermore, the metabolite profile obtained after the nasal administration of the chitosan-morphine nasal formulation was essentially identical to the one obtained for morphine administered by the intravenous route. The levels of both morphine-6-glucuronide and morphine-3-glucuronide were only about 25% of that found after oral administration of morphine. It is concluded that a properly designed nasal morphine formulation (such as one with chitosan) can result in a noninjectable opioid product capable of offering patients rapid and efficient pain relief."