http://www.erowid.org/chemicals/bzp/bzp_article1.shtmlThe action of BZP on the serotonergic system is the most studied aspect of BZP's action, as one member of the team of experimenters who did most of the research into BZP was an employee of a drug company eager to prove the serotoninomimetic action of BZP (as this indicates more action as an antidepressant, and less possibility of abuse). Results show that BZP increases the amount of serotonin (5-HT) in the extracellular fluid surrounding subcortical neurons and decreases the amount of 5-HT in cells after 14 days of treatment, indicating that BZP exhibits the now familiar amphetamine-like inhibition of reuptake and stimulation-independent release of 5-HT3. On top of this central and probably peripheral amphetamine-like action, BZP seems to be an agonist of the 5-HT2B receptor. The logic behind the conclusion that BZP acts as a direct agonist at the 5-HT2B receptor is as follows: When BZP is applied to isolated rat stomach, it causes the smooth muscle to contract, and this contraction is blocked by methergoline, indicating the process is receptor-mediated2 (methergoline has similar pKi's for all 5ht2-receptor-subtypes). This could indicate that BZP is a direct 5-HT receptor agonist, but it could also be explained by the fact that BZP causes 5-HT to be released from nerves. BZP also causes hyperthermia in rats at high ambient temperature, an effect blocked by the 5-HT antagonist cyproheptadine, but not by amitriptyline3. Amitriptyline binds to the 5-HT reuptake carrier, probably blocking BZP's amphetamine-like action. Seeing that BZP can still exhibit a serotonergic action while the stimulation-independent release of 5-HT is blocked, it must be directly activating a 5-HT receptor, and seeing that it causes stomach contraction -- which is mediated by the 5-HT2B receptor -- it must be a direct agonist at the 5-HT2B receptor. The potency of BZP at the 5-HT2B receptor must be at least 100,000 times less that 5-HT2, meaning that functionally, it is closer to an antagonist than an agonist.
Hvad alt dette vil sige har jeg ingen idé om what so ever, men ud fra det jeg kan tyde, ser det ud til at det påvirker serotoninen, ja.