Gæst skrev:
ThirdEyeFlood skrev:
Lidt om stoffets formodede virkningsmekanisme:
4-Methylmethcathinone is sympathomimetic stimulant. From proposed SAR modelling, 4-methylmethcathinone is expected to have similar pharmacological properties to methcathinone, but with increased activity on the serotonin neurotransmitter systems. Methcathinone is suggested as being more potent than its parent cathinone, and methamphetamine (1)
Methcathinone is a drug with a high abuse potential, with prolonged, high dosages known to cause psychosis and withdrawal tremors. Methcathinone is regarded as being similar in profile to methamphetamine in relation to neurotoxicity, with marked decreases in DA levels noted among abstinent users. While generally below levels associated with Parkinsons Disease, this is considered to be demonstrative of permanent, or semi permanent neurological damage (2)
Quote:
Compared with controls, abstinent methamphetamine
and methcathinone users had significant decreases in
DAT density in the caudate nucleus (223 and 224%, respectively)
and putamen (225 and 216%, respectively).
It can be speculated that the para substituted compound 4-methylmethcathinone may have reduced stimulant activity, but as said, its likely to have additional affect on serotonin via both monoamine reuptake/ SERT inhibition and direct agonist affects of the 5HT2b receptors. Concerns have been raised regarding the actions of 4-methylmethcathinone in relation to peripheral 5HT (serotonin) stimulation and how that, combined with other catecholamine activity, may be dangerous to the heart.
In a similar manner to which pulmonary hypertension is caused by peripheral 5HT produced by gastrointestinal carcinoid tumours (and some argue 5HTP), other 5HT2b agonists have been found to cause this effect, which would be exacerbated by increased DA/NE levels and their corresponding affect on the heart. Longer term, such stimulation has been shown to result in fibroblast mitosis of the mitral valve of the left atrium (specifically the Chordae Tendineae). (3,4)
While it has yet to be demonstrated by means of scientific study that 4-methylmethcathinone produces these effects, I believe it's wise to consider carefully the possible toxicity of this compound if you're intending to ingest or otherwise consume products containing this drug.
Er der evt. en der kunne forklare, hvad der sker på dansk med relativt normale ord? Bare et lille resume ville være rart.
Jo da
Det lader til at mephedrone er tæt beslægtet med methamfetamin og methcathinone, (et stof nært slægtet mdmc/methylon) Men har en større effekt på serotoninen. Det skulle også være mere potent end methamfetamin og methcathinone.
Nu ved vi jo alle at stoffer der tærer hårdt på serotoninen som f.eks mdma kan føre til kraftige depressioner og hukommelsestab. Derfor vil jeg mene i skal passe på med mephedrone drenge og piger
Det menes også at mephedrone har samme neurotoksitet som methamfetamin, hvilket vil sige at det kan være pokkers skadeligt for kroppen, og er samtidig uhyre vanedannende.
Det tyder også på at mephedrone kan gå ind og påvirke hjertet på en negativ måde, dog er der ingen konkrete beviser for dette, for ligesom at ligge det kort ud.
Der er altså en masse negative effekter ved dette stof, såsom at det muligvis kan forsage hjerteskader, krops/hjerneskader, være vanedannende og sidst men ikke mindst muligvis have nogen af de samme negative effekter som mdma.
Som jeg har nævnt, pas på! Det er stadig et RC og langt fra et uskyldigt et.
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