Rex Mundi skrev:
Jeg har taget heroin ca. 20-30 gange, altid sniffet.........
Så vidt jeg har forstået så vil diacetyl morphinen blot metabloiseres til morfin ved den indtagelses måde, dog synes jeg det lige er 10% federe end morfin.........
men altså........det stof er utroligt overvurderet, og behageligt, men ikke fantastisk........og afhængighed har jeg aldrigt mærket noget til......
Wikipedia er ambivalent mht. diacetyl-tingen og forholdet mellem heroin og morfin:
Først står der:
"When taken orally, heroin undergoes extensive first-pass metabolism via deacetylation, making it a prodrug for the systemic delivery of morphine.[10] When the drug is injected, however, it avoids this first-pass effect, very rapidly crossing the blood-brain barrier due to the presence of the acetyl groups, which render it much more lipid-soluble than morphine itself"
men derefter:
"In controlled studies comparing the physiological and subjective effects of injected heroin and morphine in individuals formerly addicted to opiates, subjects showed no preference for either drug. Equipotent, injected doses had comparable action courses, with no difference in their ability to induce euphoria, ambition, nervousness, relaxation, drowsiness, or sleepiness.[17] Data acquired from short-term addiction studies did not indicate that heroin tolerance develops more rapidly than tolerance to morphine. The findings have been discussed in relation to the physicochemical properties of heroin and morphine and the metabolism of heroin."
Er der nogen der kan sige noget mere/klogere?