Umiddelbart er der ingen hold i den påstand. En kelator trækker tvivlsomt kviksølv ud af tænderne og har indenfor medicin typisk sin brug ifbm akut toksicitet og ikke kroniske tilstande. Dernæst er den generelle konsensus at kviksølv fra fyldninger ikke bevæger sig fra tand direkte til blodbanen, men fordamper fra tanden og indåndes - hvilket igen underbygger at en kelator ikke ville trække kviksølv ud af tænderne. Udover det, er en kelator netop brugt for at udskille metaller, hvorfor det ikke burde forværre situationen men forbedre den - eller holde status quo.
Påstanden om at thioctic acid let krydser blod/hjerne barrieren og derfor trækker kviksølv med er nok lidt søgt - at thioctic acid i sig selv kan krydse barrieren let, betyder ikke at et kelat af kviksølv-thioctic acid kan krydse i samme grad.
En meget overfladisk søgning fandt yderligere info:
Citat:
Journal of Toxicology -- Clinical Toxicology. Jun2003, Vol. 41 Issue 4, p339. 9p.:
Vitamin C, Glutathione, Or Lipoic Acid Did Not Decrease Brain Or Kidney Mercury In Rats Exposed To Mercury Vapor
"Some medical practitioners prescribe GSH and vitamin C alone or in combination with DMPS or DMSA for patients with mercury exposure that is primarily due to the mercury vapor emitted by dental amalgams. Hypothesis. This study tested the hypothesis that GSH, vitamin C, or lipoic acid alone or in combination with DMPS or DMSA would decrease brain mercury. METHODS: Young rats were exposed to elemental mercury by individual nose cone, at the rate of 4.0 mg mercury per m3 air for 2 h per day for 7 consecutive days. After a 7-day equilibrium period, DMPS, DMSA, GSH, vitamin C, lipoic acid alone, or in combination was administered for 7 days and the brain and kidneys of the animals removed and analyzed for mercury by cold vapor atomic absorption. RESULTS: None of these regimens reduced the mercury content of the brain. Although DMPS or DMSA was effective in reducing kidney mercury concentrations, GSH, vitamin C, lipoic acid alone, or in combination were not. CONCLUSION: One must conclude that the palliative effect, if any, of GSH, vitamin C, or lipoic acid for treatment of mercury toxicity due to mercury vapor exposure does not involve mercury mobilization from the brain and kidney."
Hvilket tyder på at thioctic acid i ret ringe grad fungerer som kelator for kviksølv in vivo. Slet ikke i forhold til hjerne/nyre.
Citat:
Pharmacological Research, Volume 39, Issue 1, January 1999, Pages 67-80
PROTECTIVE ROLE OFdl-α-LIPOIC ACID AGAINST MERCURY-INDUCED NEURAL LIPID PEROXIDATION
"Experimental neurotoxicity in rat models was induced by an intramuscular injection of mercuric chloride.dl-α-lipoic acid was administered as an antidote in three protocols of experimental design. Two protocols of short-term exposure of mercury was designed, one with prophylactic therapy and the other with curative therapy of lipoic acid. The third protocol was with prophylactic therapy of lipoic acid on long-term exposure of mercury. Enhanced lipid peroxidation, depleted non-enzymic and perturbed enzymic antioxidant status were observed in cerebral cortex, cerebellum and sciatic nerves of the toxic groups. The ameliorating effect of lipoic acid and its therapeutic efficacy during various modes of therapy, on the antioxidant status was established in the nervous tissues."
Ergo; thioctic acid beskytter mod skader forsaget af kviksølvsalte, ikke som kelator men som antioxidant - om det gælder elementært eller organisk kviksølv i samme grad er uvist.
Sidst men ikke mindst:
Citat:
Neuroreport. 1999 Nov 26;10(17):3675-80.
Alpha-lipoic acid prevents 3,4-methylenedioxy-methamphetamine (MDMA)-induced neurotoxicity.
"A single administration of 3,4-methylenedioxymethamphetamine (MDMA, 20 mg/kg, i.p.), induced significant hyperthermia in rats and reduced 5-hydroxytryptamine (5-HT) content and [3H]paroxetine-labeled 5-HT transporter density in the frontal cortex, striatum and hippocampus by 40-60% 1 week later. MDMA treatment also increased glial fibrillary acidic protein (GFAP) immunoreactivity in the hippocampus. Repeated administration of the metabolic antioxidant alpha-lipoic acid (100 mg/kg, i.p., b.i.d. for 2 consecutive days) 30 min prior to MDMA did not prevent the acute hyperthermia induced by the drug; however, it fully prevented the serotonergic deficits and the changes in the glial response induced by MDMA. These results further support the hypothesis that free radical formation is responsible for MDMA-induced neurotoxicity."
Thioctic acid er formodentligt en ret god idé at tage, hvis man vil tage MDMA.
Håber det kan bruges, jeg ville helt klart selv indtage ALA, hvis jeg skulle tage MDMA.
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